I have extensiv time with the 338 win mag, 300 roy, 300 win. Never really gone bigger, I mean have put 4 or 5 boxes through a 375 H&H but wouldn't call it extensive. Shot at 500 Nitro express about 10 times. I liked it hit hard on both ends.
On of the farms we used to to some work on the farmer would let us shoot skunks with that and the 375.
What about the 375 Ruger then?