Gotta go with yellow #4 because in my opinion it gives you the best opportunity to kill the deer if your shot is off a bit. I'd be slightly more concerned about grazing the shoulderblad and a richochete with the lower red. I'd take the shot, it's ethical with a slug gun and I wouldn't want to take the chance of him bolting instead of walking.
I like to take the highest percentage kill shot and if the hole is visible in the mount then that's just the way it is.
I don't rush my shots, but always take the first good shot I get.
I know hunters that take the white head shot, but with CWD problem a brain shot isn't an option for me.