In South Carolina, you have nothing to worry about.
Our here, I do. Cougars, grizzlys, moose and wolves. But it doesnt stop me one bit. There is somewhat of an uneasy feeling but I will walk through the woods all night. The only reason I won't is if I put an animal to bed and dont want to bump it. I have a stand I will only hunt in the evenings because I have to go through a ditch where the deer hang out during the night for some reason. So, I will avoid walking it and bumping game.